Ena/VASP Proteins Have an Anti-Capping Independent Function in Filopodia Formation
نویسندگان
چکیده
منابع مشابه
Ena/VASP Proteins Have an Anti-Capping Independent Function in Filopodia Formation□D □V
Filopodia have been implicated in a number of diverse cellular processes including growth-cone path finding, wound healing, and metastasis. The Ena/VASP family of proteins has emerged as key to filopodia formation but the exact mechanism for how they function has yet to be fully elucidated. Using cell spreading as a model system in combination with small interfering RNA depletion of Capping Pro...
متن کاملEna/VASP proteins have an anti-capping independent function in filopodia formation.
Filopodia have been implicated in a number of diverse cellular processes including growth-cone path finding, wound healing, and metastasis. The Ena/VASP family of proteins has emerged as key to filopodia formation but the exact mechanism for how they function has yet to be fully elucidated. Using cell spreading as a model system in combination with small interfering RNA depletion of Capping Pro...
متن کاملFrom filopodia to synapses: the role of actin-capping and anti-capping proteins.
Actin-capping and anti-capping proteins are crucial regulators of actin dynamics. Recent studies have indicated that these proteins may be heavily involved in all stages of synaptogenesis, from the emergence of filopodia, through neuritogenesis and synaptic contact stabilization, to the structural changes occurring at the synapse during potentiation phenomena. In this review, we focus on recent...
متن کاملThe Eps8/IRSp53/VASP Network Differentially Controls Actin Capping and Bundling in Filopodia Formation
There is a body of literature that describes the geometry and the physics of filopodia using either stochastic models or partial differential equations and elasticity and coarse-grained theory. Comparatively, there is a paucity of models focusing on the regulation of the network of proteins that control the formation of different actin structures. Using a combination of in-vivo and in-vitro exp...
متن کاملCritical Role of Ena/VASP Proteins for Filopodia Formation in Neurons and in Function Downstream of Netrin-1
Ena/VASP proteins play important roles in axon outgrowth and guidance. Ena/VASP activity regulates the assembly and geometry of actin networks within fibroblast lamellipodia. In growth cones, Ena/VASP proteins are concentrated at filopodia tips, yet their role in growth cone responses to guidance signals has not been established. We found that Ena/VASP proteins play a pivotal role in formation ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecular Biology of the Cell
سال: 2007
ISSN: 1059-1524,1939-4586
DOI: 10.1091/mbc.e06-11-0990